The Japan Society for Menopause and Women’s Health
Journal of the Japan Society for Menopause and Women’s Health
| V0l.18-1 | V0l.18-2 | V0l.19-1 | vol.19-2 | vol.20-1 |
| vol.20-2 | vol.20-3 | vol.21-1 | vol.21-2 | vol.22-1 |
V0l.19-1
（ORIGINAL）
Review of data on women who received hormone replacement therapy at our menopausal clinic
Kazuya MAKITA 1) 2) ，Satoko MATSUMURA1) ，Yuko HORIBA1)，Akira HIRASAWA1) ,
Mariko OGAWA3) ，Ryota DESHIMARU4),Shigehisa YANAMOTO5),Kiyoshi
TAKAMATSU 3) ，
Daisuke AOKI1),And Yasunori YOSHIMURA1)
1)Department of Obstetrics & Gynecology，School of Medicine，Keio University
2)Makita Obstetrics & Gynecology Clinic
3)Department of Obstetrics &Gynecology，Tokyo Dental School
Ichikawa General Hospital
4)Department of Obstetrics & Gynecology，Eijyu General Hospital
5)Department of Obstetrics & Gynecology，Saitama Social Insurance
Hospital
＜summery>
Objectives： To review data on patients who received hormone replacement therapy (HRT) at our menopausal clinic，which was opened to establish means for the prevention and early treatment of degenerative diseases caused mainly by hypoestrogenism．
Subjects：Among 3210 women who initially presented at our clinic from April 1991 through December 2008，we studied 454 patients(mean age at start ：50.9 years old) who had continuously received HRT for at least 6 months or were still receiving HRT．Patients who were enrolled in clinical trials or received only intramuscular injections of combinations of male and
female hormones were excluded．On the basis of medical records，we survey the status of treatment from the start to the completion of HRT in patients who had already completed treatment or until the end of June 2009 in patients who continued to receive HRT．
Results：1) Of the 454 patients，127 were still receiving HRT．The longest duration of treatment was about 17 years，and 37 patients have continued to receive HRT for more than 10 years． 2) The most indication for HRT was climacteric indefinite complaints． 3) As for treatment regimens，most patients received continuous treatment with estrogens and progesterone．4)353 patients received oral tablets for HRT，the highest proportion of patients received conjugated estrogen preparations．On the other hand，101patients received transdermal medicine，and 85 patients of them received estradiol．5)The most reason for discontinuation of HRT was to make a request from patients themselves．6) The main adverse events occurring during HRT were malignant tumors in 10 patients (breast cancer in 8)
Conclusions：Our clinic was opened around the time when HRT was actively introduced to Japan．we reconfirmed that HRT makes an improvement to quality of life for middle-aged and elderly women at our menopausal clinic．
(ORIGINAL)
Menopause awareness and menopausal symptoms among community-dwelling Japanese women
Machi SUKA1), Asako TANIUCHI2), Bunpei ISHIZUKA2)
１）Department of Public Health and Environmental Medicine, the Jikei University School of Medicine
２）Department of Obstetrics and Gynecology, St.
Marianna
University
School
of Medicine
<Summary>
Objective: To examine the prevalence of menopause awareness and its association with menopausal symptoms among community-dwelling Japanese women.Methods: Cross-sectional surveys of 60- and 50-year-old women living inNorthern Kawasaki
in 2008 were conducted to collect information on menopause awareness and menopausal symptoms. The prevalence of menopause awareness and 10 subjective symptoms listed in Simplified Menopausal Index were estimated among eligible subjects without surgical menopause aged 60 years (n=938) and those aged 50 years (n=1174).Results: The prevalence of menopause awareness was 15.8% in the 60-year-old subjects, compare with 30.5% in the 50-year-old subjects (p<0.001). The most prevalent symptom was musculoskeletal pain and fatigue in both the 60- and 50-year-old subjects. The adjusted odds ratio for having menopause awareness increased with the number of subjective symptoms. Hot flashes, which were reported by 14.4% and 23.8% of the 60- and 50-year-old subjects, respectively, had a stronger association with menopause awareness than any other subjective symptoms.Conclusions: About 15% and 30% of 60- and 50-year-old women felt themselves affected by menopause. Even at the age of 60, fairly proportion of women reported menopausal symptoms.
(ORIGINAL)
Bone metabolism after cessation of long term hormone replacement therapy for postmenopausal osteoporosis
Toru Hasegawa M.D., Takao Hidaka M.D., Aiko Aoki M.D.,
Azusa
Samejima M.D.
Rika Yonezawa M.D., Tomoko Shima M.D., Akitoshi Nakashima M.D.
Shigeru Saito M.D.
Department of Obstetrics and Gynecology, Faculty of Medicine,University
of
Toyama
,
Toyama
,
Japan
<Summary>
We previously prescribed hormone replacement therapy (HRT) as the treatment of choice for postmenopausal osteoporosis. However, several studies and especially the Women’s Health Initiative (WHI) Study have shown that risks associated with HRT may outweigh the benefits. Therefore, after publication of the WHI trial findings, most regular postmenopausal HRT users tried to stop using HRT. This study investigated HRT users who had or had not continued HRT, the reasons for cessation of HRT and serial changes in BMD during HRT and several years after cessation of HRT. Ninety-four patients with osteoporosis were studied. Mean duration of HRT was 7.0±4.1 years. There was a significant difference between pretreatment BMD and the last BMD measurement during HRT. Although eleven women have continued HRT, 83 women discontinued HRT. The reasons these women stopped HRT were physician’s recommendation (38%), patient request (13.3%), adverse effects (13.3%) and complications (8.4%). Fifty-one women underwent lumbar BMD measurement after the cessation of HRT. Twenty-two of these patients were taking other drugs for osteoporosis (group B), and 18 had not taken any other drugs (group C) after estrogen removal. The mean changes in vertebral BMD following estrogen removal were significantly decreased in group C compare with that in group B. Our data show that even in women with adequate BMD after HRT, other treatment for bone loss or careful monitoring of BMD should be considered
Review of data on women who received hormone replacement therapy at our menopausal clinic
Kazuya MAKITA 1) 2) ，Satoko MATSUMURA1) ，Yuko HORIBA1)，Akira HIRASAWA1) ,
Mariko OGAWA3) ，Ryota DESHIMARU4),Shigehisa YANAMOTO5),Kiyoshi
TAKAMATSU 3) ，
Daisuke AOKI1),And Yasunori YOSHIMURA1)
1)Department of Obstetrics & Gynecology，School of Medicine，Keio University
2)Makita Obstetrics & Gynecology Clinic
3)Department of Obstetrics &Gynecology，Tokyo Dental School
Ichikawa General Hospital
4)Department of Obstetrics & Gynecology，Eijyu General Hospital
5)Department of Obstetrics & Gynecology，Saitama Social Insurance
Hospital
＜summery>
Objectives： To review data on patients who received hormone replacement therapy (HRT) at our menopausal clinic，which was opened to establish means for the prevention and early treatment of degenerative diseases caused mainly by hypoestrogenism．
Subjects：Among 3210 women who initially presented at our clinic from April 1991 through December 2008，we studied 454 patients(mean age at start ：50.9 years old) who had continuously received HRT for at least 6 months or were still receiving HRT．Patients who were enrolled in clinical trials or received only intramuscular injections of combinations of male and
female hormones were excluded．On the basis of medical records，we survey the status of treatment from the start to the completion of HRT in patients who had already completed treatment or until the end of June 2009 in patients who continued to receive HRT．
Results：1) Of the 454 patients，127 were still receiving HRT．The longest duration of treatment was about 17 years，and 37 patients have continued to receive HRT for more than 10 years． 2) The most indication for HRT was climacteric indefinite complaints． 3) As for treatment regimens，most patients received continuous treatment with estrogens and progesterone．4)353 patients received oral tablets for HRT，the highest proportion of patients received conjugated estrogen preparations．On the other hand，101patients received transdermal medicine，and 85 patients of them received estradiol．5)The most reason for discontinuation of HRT was to make a request from patients themselves．6) The main adverse events occurring during HRT were malignant tumors in 10 patients (breast cancer in 8)
Conclusions：Our clinic was opened around the time when HRT was actively introduced to Japan．we reconfirmed that HRT makes an improvement to quality of life for middle-aged and elderly women at our menopausal clinic．
(ORIGINAL)
Menopause awareness and menopausal symptoms among community-dwelling Japanese women
Machi SUKA1), Asako TANIUCHI2), Bunpei ISHIZUKA2)
１）Department of Public Health and Environmental Medicine, the Jikei University School of Medicine
２）Department of Obstetrics and Gynecology, St.
<Summary>
Objective: To examine the prevalence of menopause awareness and its association with menopausal symptoms among community-dwelling Japanese women.Methods: Cross-sectional surveys of 60- and 50-year-old women living in
(ORIGINAL)
Bone metabolism after cessation of long term hormone replacement therapy for postmenopausal osteoporosis
Toru Hasegawa M.D., Takao Hidaka M.D., Aiko Aoki M.D.,
Rika Yonezawa M.D., Tomoko Shima M.D., Akitoshi Nakashima M.D.
Shigeru Saito M.D.
Department of Obstetrics and Gynecology, Faculty of Medicine,
<Summary>
We previously prescribed hormone replacement therapy (HRT) as the treatment of choice for postmenopausal osteoporosis. However, several studies and especially the Women’s Health Initiative (WHI) Study have shown that risks associated with HRT may outweigh the benefits. Therefore, after publication of the WHI trial findings, most regular postmenopausal HRT users tried to stop using HRT. This study investigated HRT users who had or had not continued HRT, the reasons for cessation of HRT and serial changes in BMD during HRT and several years after cessation of HRT. Ninety-four patients with osteoporosis were studied. Mean duration of HRT was 7.0±4.1 years. There was a significant difference between pretreatment BMD and the last BMD measurement during HRT. Although eleven women have continued HRT, 83 women discontinued HRT. The reasons these women stopped HRT were physician’s recommendation (38%), patient request (13.3%), adverse effects (13.3%) and complications (8.4%). Fifty-one women underwent lumbar BMD measurement after the cessation of HRT. Twenty-two of these patients were taking other drugs for osteoporosis (group B), and 18 had not taken any other drugs (group C) after estrogen removal. The mean changes in vertebral BMD following estrogen removal were significantly decreased in group C compare with that in group B. Our data show that even in women with adequate BMD after HRT, other treatment for bone loss or careful monitoring of BMD should be considered